Over the past week, I’ve been scribbling some thumbnails for my hypothetical “disrobing Daisy” animation, while also trying to plot out the technical challenges that’d be involved.
Here’s a quick summary of some of those challenges –

• Untying the bow in her apron
• switching sections of cloth from normal deformers to full cloth sim
• hand/cloth collisions & interactions
• cloth/cloth collisions
• cloth/hair collisions
• changing hair styles

…with all that in mind, it’s unlikely that I’ll even attempt something like this. I’d be much better off focusing on other characters, or at least on something that wouldn’t need quite as much explaining.